This study provides some evidence that adiponectin levels may be associated with prostate cancer stage, dependent on the degree of adiposity of the man. No strong associations of adiponectin, leptin, or leptin:adiponectin ratio with grade were seen. There was no compelling evidence of associations between leptin or leptin to adiponectin ratio and prostate cancer stage. Adiponectin was inversely associated with prostate cancer stage in overweight and obese men (OR 0.62 95 % CI 0.42-0.90 p = 0.01), but not in normal weight men (OR 1.48 0.77-2.82 p = 0.24) (p for interaction 0.007), or all men (OR 0.86 0.66-1.11 p = 0.24). ≤6) by unconditional logistic regression. Associations of body mass index and adipokine levels with prostate cancer stage were determined by conditional logistic regression and with grade (Gleason score ≥7 vs. 413 men with localized ( T ≤2 & NX-0 & M0 controls) PSA-detected prostate cancer, recruited 2001-2009 from 9 UK regions to the Protec T study. We conducted a nested case-control study comparing 311 men with mainly locally advanced (≥ T 3, N1, or M1 cases) vs. We examined associations of the adipokines leptin and adiponectin with the stage and grade of PSA-detected prostate cancer. Obesity has been associated with an increased risk of advanced and fatal prostate cancer adipokines may mediate this association. All rights reserved.Īssociations of adiponectin and leptin with stage and grade of PSA-detected prostate cancer: the Protec T study.īurton, Anya Martin, Richard M Holly, Jeff Lane, J Athene Donovan, Jenny L Hamdy, Freddie C Neal, David E Tilling, Kate Estimation of the CC and millimeter ECE remains to be clarified, even if the negative predictive power for these parameters seems encouraging. Multiparametric 3 T MRI with pelvic phased-array coil appeared to be a reliable imaging technique in clinical and routine practice for the detection of localized prostate cancer.
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The estimate of the CC and ECE had a high negative predictive power with specificities and VPN respectively to 96.4% and 95.4% for CC, and 97.5 and 97.7% for ECE. The general ability of tumor detection had a sensitivity, specificity, PPV and NPV respectively to 72. Five hundred and ninety-two octants were considered with 124 significant tumors (volume ≥ 0.1cm( 3)). Three specific criteria have been sought (detection ability, capsular contact and extracapsular extension ), in comparison with the pathological data provided by the prostatectomy specimens. They all underwent multiparametric 3 T MRI with pelvic phased-array coil including T2-weighted imaging ( T2W), dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) with an ADC mapping. Prospective study of 30 months, including 74 patients for whom a diagnosis of prostate cancer had been made on randomized prostate biopsies, and all eligible to a radical prostatectomy. To analyse the detection ability of a multiparametric 3 T MRI with phased-array coil in comparison with the pathological data provided by the prostatectomy specimens. Largeron, J P Galonnier, F Védrine, N Alfidja, A Boyer, L Pereira, B Boiteux, J P Kemeny, J L Guy, L
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CONCLUSIONS These results suggest that tolerogenicity is an early and general property of prostate tumors. These responses were completely dependent on DC, but not appreciably influenced by Tregs. RESULTS HA-specific CD4 cells underwent non-immunogenic responses at all stages of tumorigenesis in both genetic backgrounds. The role of DC and Tregs in programming HA-specific CD4 cell responses were assessed via depletion. METHODS The response of naïve HA-specific CD4+ T cells were analyzed following adoptive transfer into Pro-HA Ã- TRAMP transgenic mice harboring variably- staged HA-expressing prostate tumors on two genetic backgrounds that display different patterns and kinetics of tumorigenesis. Here, we sought to determine the stage of disease progression when T cell tolerance develops, as well as the role of steady state dendritic cells (DC) and CD4+CD25+ T regulatory cells (Tregs) in programming tolerance. Adler, Adam J.īACKGROUND Prostate cancer promotes the development of T cell tolerance towards prostatic antigens, potentially limiting the efficacy of prostate cancer vaccines targeting these antigens. Dendritic Cells Program Non-Immunogenic Prostate-Specific T Cell Responses Beginning at Early Stages of Prostate Tumorigenesis